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News
The Potential of Structural Proteomics for Treating Neurodegenerative Diseases
Jan 28 2022
Read moreMRM Proteomics Inc. as a commercialization partner in newly awarded GAPP grant: $20 million invested in genomics research
Jul 19 2019
Read moreMore on the MRM Proteomics and Biodesix Collaboration
Jan 30 2019
Partners: Biodesix
Read more Read more Read morePartnership to Develop Precision Lung Cancer Diagnostics
Jan 28 2019
Partners: Biodesix
Read more Read more Read moreMRM Proteomics Inc and Exactis Innovation Partner to Establish Unique Clinical Proteomics Tools for Precision.
Sep 12 2018
Partners: Exactis Innovation
Read moreDeveloping proteomics-based tools for patient selection for clinical trials
2016
Partners: AstraZeneca, UVic, McGill
Read more Read moreDevelopment of proteomics tools including 97-protein panel for dried blood spots
Sep 18 2015
Read moreDistribution & marketing partnership with Cambridge Isotope Laboratories:
2015
Partners: Bruker
Read more Read moreDeveloping mouse proteomics tools to support drug development
2014
Partners: UVic
Read more Read moreLaunching first kits for Quality Control of MRM-MS proteomics workflows
Oct 09 2013
Partners: Bruker
Read moreEvents Calendar
Upcoming
Past
June 2022
05
June
ASMS 2022
707
Minneapolis, MN
April 2022
05
April
MSACL
09-10 Agilent Booth
Monterey, CA, USA
October 2021
31
October
05
November
ASMS 2021
Philadelphia, USA
February 2021
08
February
Virtual Workshop
Montreal, Canada
November 2019
05-08
November
Hands-On Workshop
Tübingen, Germany
05-08
November
Hands-on Workshop
Tubingen, Germany
June 2019
02-06
June
ASMS 2019
Booth #124
Atlanta, GA
May 2019
14-17
May
MRM Proteomics Hands-On Workshop
Montreal, QC
October 2018
16-19
October
MRM Proteomics Hands-On Workshop
Montreal, QC
September 2018
30
September
03
October
World HUPO 2018
Orlando, FL
23-26
September
International Congress on Personalized Healthcare 2018
Montreal, QC
June 2018
26-29
June
MRM Proteomics Hands-On Workshop
Montreal, QC
24-28
June
Metabolomics 2018
Table #5
Seattle, WA
18-21
June
World Preclinical Congress 2018
Booth #309
Boston, MA
11-12
June
Biomarkers and Immuno-Oncology World Congress 2018
Booth #36
Boston, MA
03-07
June
ASMS 2018
Booth #1122
San Diego, CA
April 2018
15-18
April
AACR 2018
Booth #3840
Chicago, IL
February 2018
12-14
February
Molecular Medicine Tri-Con 2018
Booth #208
San Francisco, CA
January 2018
23-25
January
MSACL 2018 US
Booth #21
Palm Springs, CA
November 2017
23-26
November
CONFER 2017
Iasi, Romania
October 2017
26-27
October
Companion Diagnostics (CDx) in Oncology & Beyond
Vienna, Austria
19
October
CFABS – Post-ASMS Meeting
Booth #11
Vancouver, Canada
17
October
CFABS – Post-ASMS Meeting
Booth #03
Montreal, Canada
16
October
CFABS – Post-ASMS Meeting
Booth #16
Toronto, Canada
September 2017
17-20
September
WORLD HUPO 2017
Dublin, Ireland
13-15
September
MRM-MS WORKSHOP
Sponsor
Dortmund, Germany
10-14
September
MSACL EU 2017
Booth #10
Salzburg, Austria
July 2017
17-18
July
Cascadia
Sponsor
Seattle, WA
02-08
July
3rd IMSS / 11th MSBM
Sponsor
Dubrovnik, Croatia
June 2017
26-27
June
9th Worldwide Innovation Network Symposium
Exhibitor, Booth #1
Paris, France
12-16
June
World Preclinical Congress
Exhibitor, Booth #601
Boston, MA
04-08
June
ASMS 2017
Booth #827
Indianapolis, IN
May 2017
04
May
Spring Mass Spec Group Meeting
Booth #12
Toronto, Canada
April 2017
18-20
April
CNPN 2017
Sponsor
Toronto, Canada
Selected Publications
Aug
2024
Brain Behav Immun.
Proteomic evidence of depression-associated astrocytic dysfunction in the human male olfactory bulb
Rahimian R, Perlman K, Fakhfouri G, Mpai R, Richard VR, Hercher C, Penney L, Davoli MA, Nagy C, Zahedi RP, Borchers CH, Giros B, Turecki G, Mechawar N.
Aug
2024
Cancer Res Commun.
mTORC1-Driven Protein Translation Correlates with Clinical Benefit of Capivasertib within a Genetically Preselected Cohort of PIK3CA-Altered Tumors
Sobsey CA, Froehlich BC, Mitsa G, Ibrahim S, Popp R, Zahedi RP, de Bruin EC, Borchers CH, Batist G
Jul
2024
iScience
The E3 ubiquitin ligase Nedd4L preserves skeletal muscle stem cell quiescence by inhibiting their activation
Blackburn DM, Sahinyan K, Hernández-Corchado A, Lazure F, Richard V, Raco L, Perron G, Zahedi RP, Borchers CH, Lepper C, Kawabe H, Jahani-Asl A, Najafabadi HS, Soleimani VD.
Jun
2024
Immunohorizons.
Circadian Control of the Response of Macrophages to Plasmodium Spp.-Infected Red Blood Cells
Carvalho Cabral P, Richard VR, Borchers CH, Olivier M, Cermakian N.
Apr
2024
J Proteome Res
Establishing Personalized Blood Protein Reference Ranges Using Noninvasive Microsampling and Targeted Proteomics: Implications for Antidoping Strategies
Richard VR, Mitsa G, Eshghi A, Chaplygina D, Mohammed Y, Goodlett DR, Zahedi RP, Thevis M, Borchers CH.
Apr
2024
J Proteome Res
A Simplified Proteomics LC-MRM-MS Assay for Determination of apoE Genotypes in Plasma Samples
Qasrawi DO, Al-Ghabkari A, Khan RM, Petrotchenko EV, Montero-Odasso M, Borchers CH.
Apr
2024
OMICS
Blood-Based Multiomics-Guided Detection of a Precancerous Pancreatic Tumor
Anwar MA, Keshteli AH, Yang H, Wang W, Li X, Messier HM, Cullis PR, Borchers CH, Fraser R, Wishart DS.
Feb
2024
Front Pharmacol.
Measurement of CYP1A2 and CYP3A4 activity by a simplified Geneva cocktail approach in a cohort of free-living individuals: a pilot study.
Sobsey CA, Mady N, Richard VR, LeBlanc A, Zakharov T, Borchers CH, Jagoe RT.
Jan
2024
Mol Cell Biol.
The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the ?-Subunit Gng2
Luo VM, Shen C, Worme S, Bhagrath A, Simo-Cheyou E, Findlay S, Hébert S, Wai Lam Poon W, Aryanpour Z, Zhang T, Zahedi RP, Boulais J, Buchwald ZS, Borchers CH, Côté JF, Kleinman CL, Mandl JN, Orthwein A.
Jan
2024
Commun Biol
Multiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues
Michaud SA, P?trošová H, Sinclair NJ, Kinnear AL, Jackson AM, McGuire JC, Hardie DB, Bhowmick P, Ganguly M, Flenniken AM, Nutter LMJ, McKerlie C, Smith D, Mohammed Y, Schibli D, Sickmann A, Borchers CH.
Jan
2024
J Proteome Res,
Proteomic Evolution from Acute to Post-COVID-19 Conditions.
Mohammed Y, Tran K, Carlsten C, Ryerson C, Wong A, Lee T, Cheng MP, Vinh DC, Lee TC, Winston BW, Sweet D, Boyd JH, Walley KR, Haljan G, McGeer A, Lamontagne F, Fowler R, Maslove D, Singer J, Patrick DM, Marshall JC, Murthy S, Jain F, Borchers CH, Goodlett DR, Levin A, Russell JA;
Nov
2023
Cell Rep Med
Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID.
Wang K, Khoramjoo M, Srinivasan K, Gordon PMK, Mandal R, Jackson D, Sligl W, Grant MB, Penninger JM, Borchers CH, Wishart DS, Prasad V, Oudit GY
Oct
2023
Cell Metab.
Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation.
Zhang AMY, Xia YH, Lin JSH, Chu KH, Wang WCK, Ruiter TJJ, Yang JCC, Chen N, Chhuor J, Patil S, Cen HH, Rideout EJ, Richard VR, Schaeffer DF, Zahedi RP, Borchers CH, Johnson JD, Kopp JL
Sep
2023
J Alzheimers Dis
A Metabolomics Analysis of a Novel Phenotype of Older Adults at Higher Risk of Dementia
Sultana M, Camicioli R, Dixon RA, Whitehead S, Pieruccini-Faria F, Petrotchenko E, Speechley M, Borchers CH, Montero-Odasso M
Aug
2023
Breast Cancer Res,
FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer.
Castillo-Castrejon M, Sankofi BM, Murguia SJ, Udeme AA, Cen HH, Xia YH, Thomas NS, Berry WL, Jones KL, Richard VR, Zahedi RP, Borchers CH, Johnson JD, Wellberg EA
Aug
2023
Journal of proteome research
Determination of Protein Monoclonal-Antibody Epitopes by a Combination of Structural Proteomics Methods
Petrotchenko, E. V., Nascimento, E. M., Witt, J. M., & Borchers, C. H.
Jul
2023
Anal Bioanal Chem.
Amino acid analysis for peptide quantitation using reversed-phase liquid chromatography combined with multiple reaction monitoring mass spectrometry
Qasrawi DO, Petrotchenko EV, Borchers CH.
Jun
2023
Expert Rev Proteomics
Evaluation of a ‘plug and play’ nanoflow liquid chromatography system for MS-based proteomic characterization of clinical FFPE specimens
Mitsa G, Richard VR, Majedi Y, Lafleur J, Aguilar-Mahecha A, Basik M, Borchers CH.
Jun
2023
3 Biotech.
Genome mining of Pseudomonas spp. hints towards the production of under-pitched secondary metabolites
Shahid I, Han J, Hanook S, Borchers CH, El Enshasy HA, Mehnaz S.
May
2023
J Clin Invest.
Pressure overload induces ISG15 to facilitate adverse ventricular remodeling and promote heart failure
Yerra VG, Batchu SN, Kaur H, Kabir MDG, Liu Y, Advani SL, Tran DT, Sadeghian S, Sedrak P, Billia F, Kuzmanov U, Gramolini AO, Qasrawi DO, Petrotchenko EV, Borchers CH, Connelly KA, Advani A
Mar
2023
Int J Mol Sci.
Discovery-Based Proteomics Identify Skeletal Muscle Mitochondrial Alterations as an Early Metabolic Defect in a Mouse Model of beta-Thalassemia
Reboucas P, Fillebeen C, Botta A, Cleverdon R, Steele AP, Richard V, Zahedi RP, Borchers CH, Burelle Y, Hawke TJ, Pantopoulos K, Sweeney G.
Feb
2023
Methods Mol Biol.
Bioinformatics Tools and Knowledgebases to Assist Generating Targeted Assays for Plasma Proteomics
Mohammed Y, Goodlett D, Borchers CH.
Feb
2023
Methods Mol Biol.
Absolute Quantitative Targeted Proteomics Assays for Plasma Proteins.
Mohammed Y, Goodlett D, Borchers CH.
Feb
2023
Methods Mol Biol.
Offline Peptide Fractionation and Parallel Reaction Monitoring MS for the Quantitation of Low-Abundance Plasma Proteins
Gaither C, Popp R, Richard VR, Zahedi RP, Borchers CH.
Feb
2023
Mol Cancer Ther.
Inhibition of the MNK1/2-eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer
Prabhu SA, Moussa O, Gonçalves C, LaPierre JH, Chou H, Huang F, Richard VR, Ferruzo PYM, Guettler EM, Soria-Bretones I, Kirby L, Gagnon N, Su J, Silvester J, Krisna SS, Rose AAN, Sheppard KE, Cescon DW, Mallette FA, Zahedi RP, Borchers CH, Del Rincon SV, Miller WH.
Jan
2023
Methods Mol Biol.
Proteomic Assessment of the Murine Mammary Gland Extracellular Matrix.
Preston SEJ, Richard VR, Del Rincón SV, Borchers CH, Zahedi RP.
Aug
2023
Plant Sci.
Ornamental tobacco floral nectar is a rich source of antimicrobial peptides
Parra ALC, Freitas CDT, Souza PFN, von Aderkas P, Borchers CH, Beattie GA, Silva FDA, Thornburg RW
Aug
2022
MCP
Early prediction of COVID-19 patient survival by targeted plasma multi-omics and machine learning
Richard VR, Gaither C, Popp R, Chaplygina D, Brzhozovskiy A, Kononikhin A, Mohammed Y, Zahedi RP, Nikolaev EN, Borchers CH
Jul
2022
Cancer Epidemiol Biomarkers Prev.
Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Pre-Diagnostic Blood Measurements
Smith-Byrne K, Cerani A, Guida F, Zhou S, Agudo A, Aleksandrova K, Barricarte A, Rodríguez-Barranco M, Borchers CH, Gram IT, Han J, Amos CI, Hung RJ, Grankvist K, Nøst TH, Imaz L, Chirlaque-López MD, Johansson M, Kaaks R, Kühn T, Martin RM, McKay JD, Pala V, Robbins HA, Sandanger TM, Schibli D, Schulze MB, Travis RC, Vineis P, Weiderpass E, Brennan P, Johansson M, Richards JB
Jul
2022
Matrix Biol.
Phosphorylation of eIF4E in the stroma drives the production and spatial organisation of collagen type I in the mammary gland
Preston SEJ, Bartish M, Richard VR, Aghigh A, Gonçalves C, Smith-Voudouris J, Huang F, Thebault P, Cleret-Buhot A, Lapointe R, Légaré F, Postovit LM, Zahedi RP, Borchers CH, Miller WH Jr, Del Rincón SV
May
2022
Life Sci Space Res
Characteristics of blood plasma proteome changes associated with the hemorrhagic purpura of cosmonauts on the first day after long-term space missions
Pastushkova LK, Goncharov IN, Koloteva MI, Goncharova AG, Kashirina DN, Nosovsky AM, Glebova TM, Kononikhin AS, Borchers CH, Nikolaev EN, Larina IM
Apr
2022
Int J Mol Sci?.
A Non-Hazardous Deparaffinization Protocol Enables Quantitative Proteomics of Core Needle Biopsy-Sized Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Specimens
Mitsa G, Guo Q, Goncalves C, Preston SEJ, Lacasse V, Aguilar-Mahecha A, Benlimame N, Basik M, Spatz A, Batist G, Miller WH Jr, Del Rincon SV, Zahedi RP, Borchers CH.
Apr
2022
STAR Protoc
A protocol for identifying the binding sites of small molecules on the cystic fibrosis transmembrane conductance regulator (CFTR) protein
Laselva O, Petrotchenko EV, Hamilton CM, Qureshi Z, Borchers CH, Young RN, Bear CE.
Mar
2022
J Thromb Haemost
Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower-leg injury or knee arthroscopy
Mohammed Y, Touw CE, Nemeth B, van Adrichem RA, Borchers CH, Rosendaal FR, van Vlijmen BJ, Cannegieter SC.
Feb
2022
MCP
Multiple reaction monitoring-mass spectrometry enables robust quantitation of plasma proteins regardless of whole blood processing delays that may occur in the clinic
Gaither C, Popp R, Zahedi RP, Borchers CH
Feb
2022
Brain
NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice
Jennings MJ, Kagiava A, Vendredy L, Spaulding EL, Stavrou M, Hathazi D, Grüneboom A, De Winter V, Gess B, Schara U, Pogoryelova O, Lochmüller H, Borchers CH, Roos A, Burgess RW, Timmerman V, Kleopa KA, Horvath R
Jan
2022
Analytical Chem.
The Parallel Reaction Monitoring-Parallel Accumulation-Serial Fragmentation (prm-PASEF) Approach for Multiplexed Absolute Quantitation of Proteins in Human Plasma
Brzhozovskiy A, Kononikhin A, Bugrova AE, Kovalev GI, Schmit PO, Kruppa G, Nikolaev EN, Borchers CH
Dec
2021
Chemical Review
Protein Chemistry Combined with Mass Spectrometry for Protein Structure Determination.
Petrotchenko EV, Borchers CH.
Jul
2021
Analytical Chem.
Precise Quantitation of PTEN by Immuno-MRM: A Tool To Resolve the Breast Cancer Biomarker Controversy
Ibrahim S, Lan C, Chabot C, Mitsa G, Buchanan M, Aguilar-Mahecha A, Elchebly M, Poetz O, Spatz A, Basik M, Batist G, Zahedi RP, Borchers CH.
Sep
2021
J Proteome Res.
Performance Assessment of a 125 Human Plasma Peptide Mixture Stored at Room Temperature for Multiple Reaction Monitoring-Mass Spectrometry.
Gaither C, Popp R, Borchers SP, Skarphedinsson K, Eiriksson FF, Thorsteinsdóttir M, Mohammed Y, Borchers CH.
Apr
2021
Proteome Res.
An Update on MRMAssayDB: A Comprehensive Resource for Targeted Proteomics Assays in the Community
Bhowmick P, Roome S, Borchers CH, Goodlett DR, Mohammed Y
Jan
2021
Bioinformatics
Mouse Quantitative Proteomics Knowledgebase: reference protein concentration ranges in 20 mouse tissues using 5000 quantitative proteomics assays.
Mohammed Y, Bhowmick P, Michaud SA, Sickmann A, Borchers CH.
Jul
2020
Proteomics Clin Appl.
Systematic Optimization of the iMALDI Workflow for the Robust and Straightforward Quantification of Signaling Proteins in Cancer Cells
Froehlich BC, Popp R, Sobsey CA, Ibrahim S, LeBlanc AM, Mohammed Y, Aguilar-Mahecha A, Poetz O, Chen MX, Spatz A, Basik M, Batist G, Zahedi RP, Borchers CH.
May
2020
Proteomics
Targeted and Untargeted Proteomics Approaches in Biomarker Development
Sobsey CA, Ibrahim S, Richard VR, Gaspar V, Mitsa G, Lacasse V, Zahedi RP, Batist G, Borchers CH.
May
2020
Analyst
Determination of the concentration range for 267 proteins from 21 lots of commercial human plasma using highly multiplexed multiple reaction monitoring mass spectrometry
Gaither C, Popp R, Mohammed Y, Borchers CH.
Aug
2019
Cell Reports
Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium
Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T
Jun
2019
Methods in Molecular Biology
Mass Spectrometric Determination of Protein Ubiquitination
Parker CE, Warren Hines MRE, Mocanu V, Greer SF, Borchers CH
Jun
2019
Nature Methods
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD
Jun
2019
Journal of Biological Chemistry
Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency
Mao F, Liu T, Hou X, Zhao H, He W, Li C, Jing Z, Sui J, Wang F, Liu X, Han J, Borchers CH, Wang JS, Li W
May
2019
Analytical Chemistry
The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study
Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews PC, Bernfur K, Borchers CH, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis TN, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez CB, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukacka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Fereira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko EV, Piersimoni L, Plasencia M, Pukala TL, Rand KD, Rappsilber J, Reichman D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka MJ, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz DS, Leitner A, Sinz A
Mar
2019
PLOS Computational Biology
Conformational ensemble of native alpha-synuclein in solution as determined by short-distance crosslinking constraint-guided discrete molecular dynamics simulations
Brodie NI, Popov KI, Petrotchenko EV, Dokholyan NV, Borchers CH
Mar
2019
BMC Medical Genomics
The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins
Kashirina DN, Percy AJ, Pastushkova LK, Borchers CH, Kireev KS, Ivanisenko VA, Kononikhin AS, Nikolaev EN, Larina IM
Feb
2019
Nature communications
Chaperone activation and client binding of a 2-cysteine peroxiredoxin
Teixeira F, Tse E, Castro H, Makepeace KA, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U
Jan
2019
PROTEOMICS - Clinical Applications
Multiplexed LC/ESI-MRM-MS-based Assay for Identification of Coronary Artery Disease Biomarkers in Human Plasma
Anwar MA, Dai DL, Wilson-McManus J, Smith D, Francis GA, Borchers CH, McManus BM, Hill JS, Cohen Freue GV
Jan
2018
Journal of molecular biology
Changing the Apoptosis Pathway through Evolutionary Protein Design
Shultis D, Mitra P, Huang X, Johnson J, Khattak NA, Gray F, Piper C, Czajka J, Hansen L, Wan B, Chinnaswamy K, Liu L, Wang M, Pan J, Stuckey J, Cierpicki T, Borchers CH, Wang S, Lei M, Zhang Y
Nov
2018
Journal of lipid research
Hydrophilic bile acids prevent liver damage caused by lack of biliary phospholipid in Mdr2-/- mice
Wang R, Sheps JA, Liu L, Han J, Chen PS, Lamontagne J, Wilson PD, Welch I, Borchers CH, Ling V
Sep
2018
Expert review of proteomics
Immuno-MALDI (iMALDI) mass spectrometry for the analysis of proteins in signaling pathways
Popp R, Li H, Borchers CH
Sep
2018
bioRxiv
Cross-linking/Mass Spectrometry: A Community-Wide, Comparative Study Towards Establishing Best Practice Guidelines
Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Borchers C, Brodie NI, Bruce JE, Chaignepain S, Chavez JD, Claverol S, Cox J, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Goetze M, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukacka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Ninnis R, Novak P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel MJ, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A
Aug
2018
Biomarkers
Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study
Penn AM, Bibok MB, Saly VK, Coutts SB, Lesperance ML, Balshaw RF, Votova K, Croteau NS, Trivedi A, Jackson AM, Hegedus J, Klourfeld E, Yu AYX, Zerna C, Modi J, Barber PA, Hoag G, Borchers CH, SpecTRA study group
Aug
2018
Clinical chemistry
Immuno-MALDI-TOF-MS in the Clinic
Zahedi RP, Parker CE, Borchers CH
Aug
2018
bioRxiv
MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2
de Paz AM, Khajavi L, Martin H, Claveria-Gimeno R, tom Dieck S, Cheema MS, Sanchez-Mut JV, Moksa M, Carles A, Brodie N, Sheikh TI, Freeman M, Petrotchenko E, Borchers CH, Schuman E, Zytnicki M, Velazquez-Campoy A, Abian O, Hirst M, Esteller M, Vincent J, Malnou CE, Ausio J
Jul
2018
Expert review of proteomics
Detecting post-translational modification signatures as potential biomarkers in clinical mass spectrometry
Mnatsakanyan R, Shema G, Basik M, Batist G, Borchers CH, Sickmann A, Zahedi RP
Jun
2018
Communications biology
Molecular phenotyping of laboratory mouse strains using 500 multiple reaction monitoring mass spectrometry plasma assays
Michaud SA, Sinclair NJ, Petrošová H, Palmer AL, Pistawka AJ, Zhang S, Hardie DB, Mohammed Y, Eshghi A, Richard VR, Sickmann A, Borchers CH
Jun
2018
PROTEOMICS - Clinical Applications
Maternal Apolipoprotein B100 Serum Levels are Diminished in Pregnancies with Intrauterine Growth Restriction and Differentiate from Controls
Wölter M, Okai CA, Smith DS, Ruß M, Rath W, Pecks U, Borchers CH, Glocker MO
Jun
2018
Journal of proteome research
Genetic Variation in 9p21 and the Plasma Proteome
Mahdavi S, Jenkins DJ, Borchers CH, El-Sohemy A
May
2018
Bioinformatics
MRMAssayDB: an integrated resource for validated targeted proteomics assays
Bhowmick P, Mohammed Y, Borchers CH
May
2018
Analyst
How iMALDI can improve clinical diagnostics
Popp R, Basik M, Spatz A, Batist G, Zahedi RP, Borchers CH
Mar
2018
Genetics in Medicine
Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy–like disease
Boczonadi V, King MS, Smith AC, Olahova M, Bansagi B, Roos A, Eyassu F, Borchers C, Ramesh V, Lochmüller H, Polvikoski T, Whittaker RG, Pyle A, Griffin H, Taylor RW, Chinnery PF, Robinson AJ, Kunji ERS, Horvath R
Mar
2018
Nucleic Acids Research
The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability
Dilworth D, Gudavicius G, Xu X, Boyce AK, O’Sullivan C, Serpa JJ, Bilenky M, Petrochenko EV, Borchers CH, Hirst M, Swayne LA, Howard P, Nelson CJ.
Mar
2018
PROTEOMICS – Clinical Applications
The Special Issue: Clinical Proteomics for Precision Medicine
Parker CE, Borchers CH.
Feb
2018
Liver International
Comprehensive bile acid profiling in hereditary intrahepatic cholestasis: Genetic and clinical correlations.
Liu T, Wang RX, Han J, Hao CZ, Qiu YL, Yan YY, Li LT, Wang NL, Gong JY, Lu Y, Zhang MH, Xie CB, Yang JC, You YJ, Li JQ, Knisely AS, Borchers CH, Ling V, Wang JS.
Feb
2018
Clinical Chemistry
Short-term stabilities of 21 amino acids in dried blood spots
Han J, Higgins R, Lim MD, Lin K, Yang J, Borchers CH
Feb
2018
Biomarkers
Verification of a proteomic biomarker panel to diagnose minor stroke and transient ischaemic attack: phase 1 of SpecTRA, a large scale translational study
Penn AM, Bibok MB, Saly VK, Coutts SB, Lesperance ML, Balshaw RF, Votova K, Croteau NS, Trivedi A, Jackson AM, Hegedus J, Klourfeld E, Yu AYX, Zerna C, Borchers CH
Feb
2018
Analytica Chimica Acta
Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots
Han J, Higgins R, Lim MD, Atkinson K, Yang J, Lin K, Borchers CH.
Feb
2018
General and Comparative Endocrinology
Metabolomic insights into the effects of thyroid hormone on Rana (Lithobates) catesbeiana metamorphosis using whole-body Matrix Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI)
Luehr TC, Koide EM, Wang X, Han J, Borchers CH, Helbing CC.
Jan
2018
Translational stroke research
Differential Proteomics for Distinguishing Ischemic Stroke from Controls: a Pilot Study of the SpecTRA Project
Penn AM, Saly V, Trivedi A, Lesperance ML, Votova K, Jackson AM, Croteau NS, Balshaw RF, Bibok MB, Smith DS, Lam KK, Morrison J, Lu L, Coutts SB, Borchers CH
Jan
2018
Analytical Chemistry
Top-down hydrogen-deuterium exchange analysis of protein structures using ultraviolet photodissociation (UVPD)
Brodie NI, Huguet R, Zhang T, Viner R, Zabrouskov V, Pan J, Petrotchenko EV, Borchers CH.
Jan
2018
Journal of Proteome Research
Proteomic profiling of Leishmania donovani promastigote subcellular organelles
Jardim A, Hardie DB, Boitz J, Borchers CH.
Jan
2018
PROTEOMICS – Clinical Applications
An MRM-Based Cytokeratin Marker Assay as a Tool for Cancer Studies: Application to Lung-Cancer Pleural Effusions
Perzanowska A, Fatalska A, Wojtas G, Lewandowicz A, Michalak A, Krasowski G, Borchers CH, Dadlez M, Domanski D
Dec
2017
Environmental Earth Sciences
Profiling of dissolved organic compounds in the oil sands region using complimentary liquid–liquid extraction and ultrahigh resolution Fourier transform mass spectrometry
Yi Y, Han J, Birks SJ, Borchers CH, Gibson JJ.
Dec
2017
Blood
Systemic Biomarkers Show Elevated Oxidative Stress and Chronic Inflammation in Two Disorders of Neurodegeneration with Brain Iron Accumulation (NBIA).
Minkley M, Sweeters N, Kasravi S, Ferguson J, Higa A, Jackson A, Smith D, Borchers C, Nashmi R, Macleod P, Neumayr LD.
Dec
2017
Methods in Molecular Biology
Sep
2017
PROTEOMICS - Clinical Applications
ExSTA: External Standard Addition Method for Accurate High?Throughput Quantitation in Targeted Proteomics Experiments
Mohammed Y, Pan J, Zhang S, Han J, Borchers CH
Sep
2017
Journal of Proteomics
An online 2D-reversed-phase–Reversed-phase chromatographic method for sensitive and robust plasma protein quantitation
Richard VR, Domanski D, Percy AJ, Borchers CH.
Sep
2017
Nucleic Acids Research
The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module.
Dilworth D, Upadhyay SK, Bonnafous P, Edoo AB, Bourbigot S, Pesek-Jardim F, Gudavicius G, Serpa JJ, Petrotchenko EV, Borchers CH, Nelson CJ.
Sep
2017
Analytical Chemistry
Immuno-Matrix-Assisted Laser Desorption/Ionization Assays for Quantifying AKT1 and AKT2 in Breast and Colorectal Cancer Cell Lines and Tumors
Popp R, Li H, LeBlanc A, Mohammed Y, Aguilar-Mahecha A, Chambers AG, Lan C, Poetz O, Basik M, Batist G, Borchers CH
Aug
2017
Journal of Visualized Experiments: JOVE
Peptide and Protein Quantification Using Automated Immuno-MALDI (iMALDI).
Li H, Popp R, Frohlich B, Chen MX, Borchers CH.
Aug
2017
Scientific Reports
Protein expression changes caused by spaceflight as measured for 18 Russian cosmonauts.
Larina I, Percy AJ, Yang J, Borchers CH, Nosovsky A, Grigoriev A, Nikolaev E
Aug
2017
Scientific Reports
Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees
Guarna MM, Hoover SE, Huxter E, Higo H, Moon KM, Domanski D, Bixby ME, Melathopoulos AP, Ibrahim A, Peirson M, Desai S, Micholson D, White R, Borchers CH, Currie RW, Pernal SF, Foster LJ
Jul
2017
Biochimica et Biophysica Acta (BBA) – Proteins & Proteomics
Metabolomic profiling of prostate cancer by matrix assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry imaging using Matrix Coating Assisted by an Electric Field (MCAEF).
Wang X, Han J, Hardie DB, Yang J, Pan J, Borchers CH.
Jul
2017
Science Advances
Solving protein structures using short-distance cross-linking constraints as a guide for discrete molecular dynamics simulations
Brodie NI, Popov KI, Petrotchenko EV, Dokholyan NV, Borchers CH.
Jun
2017
Journal of Proteome Research
Multiplexed MRM-based protein quantitation using two different stable isotope-labeled peptide Isotopologues for calibration
LeBlanc A, Michaud SA, Percy AJ, Hardie DB, Yang J, Sinclair NJ, Proudfoot JI, Pistawka A, Smith DS, Borchers CH.
Jun
2017
Journal of Neurotrauma
A targeted proteomics analysis of cerebrospinal fluid after acute human spinal cord injury
Streijger F, Skinnider MA, Rogalski JC, Balshaw R, Shannon CP, Prudova A, Belanger L, Ritchie L, Tsang A, Christie S, Parent S, Mac-Thiong JM, Bailey C, Urquhart J, Ailon T, Paquette S, Boyd M, Street J, Fisher CG, Dvorak MF, Borchers CH, Foster LJ, Kwon BK
Jun
2017
Blood Advances
Multiplexed targeted proteomic assay to assess coagulation factor concentrations and thrombosis-associated cancer
Mohammed Y, van Vlijmen BJ, Yang J, Percy AJ, Palmblad M, Borchers CH, Rosendaal FR.
May
2017
Hepatology
Defects in myosin VB are associated with a spectrum of previously undiagnosed low y-glutamyltransferase cholestasis
Qiu YL, Gong JY, Feng JY, Wang RX, Han J, Liu T, Lu Y, Li LT, Zhang MH, Sheps JA, Wang NL, Yan YY, Li JQ, Chen L, Borchers CH, Sipos B, Knisely AS, Ling V, Xing QH, Wang JS
May
2017
TrAC Trends in Analytical Chemistry
Affinity-mass spectrometric technologies for quantitative proteomics in biological fluids
Li H, Popp R, Borchers CH
May
2017
Journal of Mass Spectrometry
Current trends in quantitative proteomics – an update
Li H, Han J, Pan J, Liu T, Parker CE, Borchers CH
May
2017
United States Patent Application
System and method for matrix-coating samples for mass spectrometry
Borchers CH, Han J, Wang X
Apr
2017
The Journal of Infectious Diseases
Enteric helminths promote Salmonella coinfection by altering the intestinal metabolome
Reynolds LA, Redpath SA, Yurist-Doutsch S, Gill N, Brown EM, van der Heijden J, Brosschot TP, Han J, Marshall NC, Woodward SE, Valdez Y, Borchers CH, Perona-Wright G, Finlay BB.
Mar
2017
Analytical Chemistry
Bead-Extractor Assisted Ready-to-use reagent System (BEARS) for immunoprecipitation coupled to MALDI-MS
Li H, Popp R, Chen M, MacNamara EM, Juncker D, Borchers CH
Mar
2017
Journal of Clinical Microbiology
Characterization and diagnostic application of Trypanosoma cruzi trypomastigote excreted-secreted antigens shed in extracellular vesicles released from infected mammalian cells
Bautista-López NL, Ndao M, Camargo FV, Nara T, Annoura T, Hardie DB, Borchers CH, Jardim A
Mar
2017
Molecular & Cellular Proteomics
New guidelines for publication of manuscripts describing development and application of targeted mass spectrometry measurements of peptides and proteins
Abbatiello S, Ackermann BL, Borchers C, Bradshaw RA, Carr SA, Chalkley R, Choi M, Deutsch E, Domon B, Hoofnagle AN, Keshishian H, Kuhn E, Liebler DC, MacCoss M, MacLean B, Mani DR, Neubert H, Smith D, Vitek O, Zimmerman L.
Feb
2017
Journal of Proteome Research
Feb
2017
Proteomics. Methods in Molecular Biology
Pathway-Informed Discovery and Targeted Proteomic Workflows Using Mass Spectrometry.
Chu CS, Miller CA, Gieschen A, Fischer SM
Dec
2016
Biochimica et Biophysica Acta (BBA) – Proteins & Proteomics
Dec
2016
Proteomics
PeptideTracker: A knowledge base for collecting and storing information on protein concentrations in biological tissues
Mohammed Y, Bhowmick P, Smith DS, Domanski D, Jackson AM, Michaud SA, Malchow S, Percy AJ, Chambers AG, Palmer A, Zhang S, Sickmann A, Borchers CH
Dec
2016
Modern Proteomics – Sample Preparation, Analysis and Practical Applications
Protocol for Standardizing High-to-Moderate Abundance Protein Biomarker Assessments Through an MRM-with-Standard-Peptides Quantitative Approach
Percy AJ, Yang J, Chambers AG, Mohammed Y, Miliotis T, Borchers CH
Oct
2016
Proteomics
Multiplexed panel of precisely quantified salivary proteins for biomarker assessment.
Percy AJ, Hardie DB, Jardim A, Yang J, Elliott MH, Zhang S, Mohammed Y, Borchers CH
Sep
2016
Proteomics
Multiplexed MRM-based assays for the quantitation of proteins in mouse plasma and heart tissue.
Percy AJ, Michaud SA, Jardim A, Sinclair NJ, Zhang S, Mohammed Y, Palmer AL, Hardie DB, Yang J, LeBlanc AM, Borchers CH.
Feb
2016
Journal of Proteomics
Protein species-specific characterization of conformational change induced by multisite phosphorylation.
Pan J, Zhang S, Borchers CH.
Dec
2015
Bioanalysis
A standardized kit for automated quantitative assessment of candidate protein biomarkers in human plasma
Percy AJ, Mohammed Y, Yang J, Borchers CH.
Dec
2015
Bioanalysis
Absolute quantification of 35 plasma biomarkers in human saliva using targeted MS
Hirtz C, Vialaret J, Nowak N, Gabelle A, Deville de Périère D, Lehmann S
Nov
2015
Chemical Science
Higher-order structural interrogation of antibodies using middle-down hydrogen/deuterium exchange mass spectrometry.
Pan J, Zhang S, Chou A, Borchers CH.
Sep
2015
EuPA Open Proteomics
Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment.
Percy AJ, Tamura-Wells J, Albar JP, Aloria K, Amirkhani A, Araujo GD, Arizmendi JM, Blanco FJ, Canals F, Cho JY, Colomé-Calls N, ... , Borchers CH
null
2015
Inflammatory Pathways in Diabetes
Jun
2014
Journal of Proteome Research
Multiplexed MRM with internal standards for cerebrospinal fluid candidate protein biomarker quantitation.
Percy AJ, Yang J, Chambers AG, Simon R, Hardie DB, Borchers CH.
Jan
2014
Expert Review of Proteomics
Targeted quantitation of CVD-linked plasma proteins for biomarker verification and validation.
Percy AJ, Byrns S, Chambers AG, Borchers CH.